Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558248 | 0.87 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6558265 | 0.83 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AKDM4EAPP | |
| SCHEMBL6254330 | 0.80 | MAPT (0.51) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL6557408 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL30990618 | 0.75 | MAPT (0.54) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9259108 | 0.75 | MAPT (0.54) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL2281435 | 0.71 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ALMNAKDM4E | |
| SCHEMBL194639 | 0.69 | KDM1A (0.50) | ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4169410 | 0.68 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL1680858 | 0.67 | MEN1 (0.40) | MEN1KMT2ARAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392643-A2 | TRISUBSTITUTED-N- (1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002094767-A2 | TRISUBSTITUTED-N-[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS | ABBOTT LABORATORIES (US) | 2002-11-28 | — | — | WO | disclosed |