SCHEMBL6558248

SCHEMBL6558248

Brc1cccc(C2OCCO2)c1.O=Cc1cccc(Sc2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
KDM1A O60341 4/20 0.34
RCOR1 Q9UKL0 2/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
HDAC4 P56524 2/20 0.33
CYP2A6 P11509 1/20 0.30
HSD11B1 P28845 1/20 0.30
HDAC3 O15379 1/20 0.30
HDAC1 Q13547 1/20 0.30
HDAC7 Q8WUI4 1/20 0.30
HDAC2 Q92769 1/20 0.30
HDAC10 Q969S8 1/20 0.30
HDAC11 Q96DB2 1/20 0.30
HDAC8 Q9BY41 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30
HDAC9 Q9UKV0 1/20 0.30
HDAC5 Q9UQL6 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6558265 0.88 ALDH1A1 (0.38) ALDH1A1MAOAMAOBCYP2A6MEN1
SCHEMBL6557103 0.87 ALDH1A1 (0.37) ALDH1A1MEN1KMT2A
SCHEMBL6557408 0.87 ALDH1A1 (0.45) ALDH1A1KDM1ARCOR1MAOAMAOB
SCHEMBL1680858 0.79 MEN1 (0.40) MAOAMAOBMEN1KMT2A
SCHEMBL2281435 0.77 ALDH1A1 (0.42) ALDH1A1MAOAMAOBCYP2A6MEN1
SCHEMBL1681164 0.76 ALDH1A1 (0.52) ALDH1A1MAOAMAOBHDAC4CYP2A6
SCHEMBL31618073 0.76 ALDH1A1 (0.52) ALDH1A1MAOAMAOBHDAC4CYP2A6
SCHEMBL194639 0.76 KDM1A (0.50) ALDH1A1KDM1ARCOR1HDAC4MEN1
SCHEMBL6196036 0.72 DRD2 (0.42) ALDH1A1MAOAMAOBCYP2A6MEN1
SCHEMBL29995306 0.72 DRD2 (0.42) ALDH1A1MAOAMAOBCYP2A6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392643-A2 TRISUBSTITUTED-N- (1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS Abbott Laboratories (US) 2004-03-03 EP disclosed
WO-2002094767-A2 TRISUBSTITUTED-N-[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS ABBOTT LABORATORIES (US) 2002-11-28 WO disclosed