SCHEMBL6557516

SCHEMBL6557516

COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1OC

nearest known ligand 0.65

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.65
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
MAPT P10636 3/20 0.54
CYP2C9 P11712 3/20 0.54
ESR1 P03372 1/20 0.53
AURKA O14965 1/20 0.51
DHFR P00374 1/20 0.51
TSHR P16473 1/20 0.51
SMN1; SMN2 Q16637 4/20 0.51
ALDH1A1 P00352 3/20 0.51
CYP3A4 P08684 3/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 2/20 0.50
CYP2C19 P33261 3/20 0.48
HTR6 P50406 3/20 0.47
HIF1A Q16665 1/20 0.47
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14478904 0.91 LMNA (0.61) LMNAMEN1KMT2AMAPTCYP2C9
SCHEMBL10540044 0.86 LMNA (0.55) LMNAMEN1KMT2AMAPTCYP2C9
Sulfameter SCHEMBL79417 0.79 LMNA (1.00) LMNAMEN1KMT2AMAPTCYP2C9
Sulfameter SCHEMBL11137116 0.78 LMNA (0.97) LMNAMEN1KMT2AMAPTCYP2C9
Sulfameter SCHEMBL27709233 0.78 LMNA (0.97) LMNAMEN1KMT2AMAPTCYP2C9
Sulfameter SCHEMBL17593237 0.78 LMNA (0.97) LMNAMEN1KMT2AMAPTCYP2C9
SCHEMBL2176380 0.76 MAPT (0.68) LMNAMEN1KMT2AMAPTCYP2C9
SCHEMBL6557184 0.75 MAPT (0.63) LMNAMEN1KMT2AMAPTCYP2C9
SCHEMBL9732799 0.75 DHFR (0.58) LMNAMEN1KMT2ADHFRTSHR
Sulfameter SCHEMBL28250749 0.75 LMNA (0.89) LMNAMEN1KMT2AMAPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200038399-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION Motif BioSciences Inc. 2020-02-06 US claimed
EP-3538094-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION Motif Biosciences, Inc. (US) 2019-09-18 EP claimed
WO-2018144086-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION MOTIF BIOSCIENCES, INC. (US) 2018-08-09 WO claimed
US-20180133218-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION HERCULES TECHNOLOGY MANAGEMENT CO III LLC 2018-05-17 US claimed
US-4315931-A MICROBIOCIDES, INFECTIOUS DISEASES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US claimed
US-20200038399-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION Motif BioSciences Inc. 2020-02-06 US disclosed
EP-3538094-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION Motif Biosciences, Inc. (US) 2019-09-18 EP disclosed
WO-2018144086-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION MOTIF BIOSCIENCES, INC. (US) 2018-08-09 WO disclosed
US-20180133218-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION HERCULES TECHNOLOGY MANAGEMENT CO III LLC 2018-05-17 US disclosed
EP-1230224-B1 SUBSTITUTED 5-BENZYL-2,4-DIAMINOPYRIMIDINES BASILEA PHARMACEUTICA AG (CH) 2004-12-29 EP disclosed
EP-1278742-B1 CHROMENYLMETHYLPYRIMIDINEDIAMINES AS ANTIBACTERIAL AGENTS BASILEA PHARMACEUTICA AG (CH) 2004-12-15 EP disclosed
US-6818649-B2 5-(8-ALKOXY)-2,2-SUBSTITUTED-2H-CHROMEN-6-YLMETHYL)-PYRIMIDINE-2,4 -DIAMINE DERIVATIVES USEFUL FOR TREATING INFECTIOUS DISEASES BASILEA PHARMACEUTICA AG (CH) 2004-11-16 US disclosed
US-4189581-A BACTERICIDES, POTENTIATORS OF SULFA DRUGS BASF AKTIENGESELLSCHAFT (DE) 1980-02-19 US disclosed
EP-0000335-A1 Esters of N-pyrimidinyl-carboximidic acid, process for their preparation and medicines containing them. BASF Aktiengesellschaft (DE) 1979-01-24 EP disclosed
EP-0000336-A1 N-benzylpyrimidinyl-amidines, process for their preparation and medicines containing them BASF Aktiengesellschaft (DE) 1979-01-24 EP disclosed
EP-0000334-A1 2,4-Diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them BASF Aktiengesellschaft (DE) 1979-01-24 EP disclosed
US-4076810-A Benzylpyrimidine antibacterial composition HOFFMANN-LA ROCHE INC. (US) 1978-02-28 US disclosed
US-4039543-A SUBSTITUTED BY AMINE, N-RING, AMIDE, CARBAMATE, UREA HOFFMANN-LA ROCHE INC. (US) 1977-08-02 US disclosed
US-4024145-A Benzylpyrimidine derivatives HOFFMANN-LA ROCHE INC. (US) 1977-05-17 US disclosed
US-3931181-A BACTERICIDE HOFFMANN-LA ROCHE INC. (US) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180133218-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION NISCH, KIT, MGAM LMNA 852/4885MEN1 1282/4885KMT2A 524/4885
US-20200038399-A1 FORMULATIONS, METHODS, KIT, AND DOSAGE FORMS FOR TREATING BACTERIAL INFECTION NISCH, KIT, MGAM LMNA 852/4885MEN1 1282/4885KMT2A 524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.