SCHEMBL6557772

SCHEMBL6557772

CCOc1cccc(OCCN)c1OC(=O)CC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.43
L3MBTL1 Q9Y468 7/20 0.41
MAPT P10636 3/20 0.41
NPSR1 Q6W5P4 1/20 0.41
HTR1B P28222 1/20 0.41
GLA P06280 1/20 0.41
TDP1 Q9NUW8 1/20 0.40
PLAU P00749 1/20 0.39
ALDH1A1 P00352 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPK1 P28482 2/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HTR1A P08908 1/20 0.37
ADRA1D P25100 1/20 0.37
ADRA1A P35348 1/20 0.37
ADRA1B P35368 1/20 0.37
CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15558253 0.86 L3MBTL1 (0.46) KDM4EL3MBTL1MAPTGLAALDH1A1
SCHEMBL6055987 0.83 ALDH1A1 (0.47) L3MBTL1MAPTGLAALDH1A1KMT2A
SCHEMBL1096226 0.82 ALDH1A1 (0.51) KDM4EL3MBTL1MAPTGLATDP1
SCHEMBL7617609 0.82 ALDH1A1 (0.46) L3MBTL1MAPTGLAALDH1A1KMT2A
SCHEMBL15558679 0.81 ALDH1A1 (0.44) KDM4EL3MBTL1GLAALDH1A1MEN1
SCHEMBL6065085 0.80 MAPT (0.44) L3MBTL1MAPTGLAALDH1A1MEN1
SCHEMBL15547824 0.80 NPC1 (0.40) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL15548129 0.79 CYP1A2 (0.44) KDM4EMAPTMEN1KMT2ACYP1A2
SCHEMBL7636675 0.78 MRGPRX4 (0.57) KDM4EL3MBTL1MAPTGLATDP1
SCHEMBL15548355 0.78 MEN1 (0.49) KDM4EMAPTNPSR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1073643-B1 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM REDDYS LAB LTD DR (IN) 2004-12-29 EP disclosed
EP-1073643-A2 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-02-07 EP disclosed
WO-1999008501-A2 NEW HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1999-02-25 WO disclosed