SCHEMBL6557980

SCHEMBL6557980

CS(=O)(=O)c1ccc(C(=O)C(C#N)C(=O)C2CC2)c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.41
MAPT P10636 4/20 0.39
GAA P10253 1/20 0.39
RAB9A P51151 1/20 0.39
CACNA1B Q00975 2/20 0.39
NR1I2 O75469 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP2C19 P33261 1/20 0.38
PPARG P37231 1/20 0.38
NCOA2 Q15596 1/20 0.38
NCOA1 Q15788 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
AVPR2 P30518 1/20 0.38
GPR27 Q9NS67 1/20 0.38
GPR6 P46095 1/20 0.37
SMO Q99835 1/20 0.36
DPP4 P27487 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8606503 0.88 POLB (0.38) MAPTALDH1A1
SCHEMBL8609476 0.86 DPP4 (0.36) LMNAMEN1KMT2ADPP4
SCHEMBL8608727 0.86 NR1I2 (0.39) CACNA1BNR1I2
SCHEMBL8606555 0.83 LMNA (0.43) LMNAMAPTGAARAB9AMEN1
SCHEMBL8607171 0.83 CACNA1B (0.43) CACNA1BNR1I2CYP2C19
SCHEMBL2204128 0.81 LMNA (0.43) LMNAMAPTGAARAB9ACACNA1B
SCHEMBL8606438 0.81 SLC6A2 (0.32) LMNA
SCHEMBL1740206 0.81 F10 (0.37) KMT2AALDH1A1NPSR1AVPR2GPR27
SCHEMBL29355315 0.81 F10 (0.37) KMT2AALDH1A1NPSR1AVPR2GPR27
SCHEMBL8607649 0.81 LMNA (0.43) LMNAMAPTGAARAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6713434-B2 CONTROL OF WEEDS USING A SYNERGISTIC MIXTURE OF A UREA HERBICIDE AND EITHER A 4-BENZOYLISOXAZOLE OR A 2-CYANO-1,3-DIONE HERBICIDE; FOR EXAMPLE, TEBUTHIURON AND ISOXAFLUTOLE ON CEREAL OR SUGAR CANE CROPS RHONE-POULENC AGRO (FR) 2004-03-30 US claimed
EP-1032267-B1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS BAYER CROPSCIENCE SA (FR) 2004-03-10 EP claimed
US-20030060368-A1 Control of weeds using a synergistic mixture of a urea herbicide and either a 4-benzoylisoxazole or a 2-cyano-1,3-dione herbicide; for example, tebuthiuron and isoxaflutole on cereal or sugar cane crops MILLET JEAN-CLAUDE (FR) 2003-03-27 US claimed
US-20010016560-A1 Herbicidal compositions MILLET JEAN-CLAUDE (FR) 2001-08-23 US claimed
EP-1032267-A1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS AVENTIS CROPSCIENCE S.A. (FR) 2000-09-06 EP claimed
US-6069115-A BY A SINGLE POST-EMERGENT APPLICATION OF A GLYPHOSATE HERBICIDE, AND A GIVEN DERIVATIVES OF P-HYDROXYPHENYLPYRUVATE DIOXYGENASE(HPPD)-INHIBITING HERBICIDES TO GLYPHOSATE TOLERANT CROPS RHONE-POULENC AGROCHIMIE (FR) 2000-05-30 US claimed
WO-1999023886-A1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS AVENTIS CROPSCIENCE S.A. (FR) 1999-05-20 WO claimed
EP-0496630-B1 2-Cyano-1,3-dione herbicides RHONE POULENC AGRICULTURE (GB) 1995-06-07 EP claimed
EP-0496630-A1 2-Cyano-1,3-dione herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1992-07-29 EP claimed
US-6713434-B2 CONTROL OF WEEDS USING A SYNERGISTIC MIXTURE OF A UREA HERBICIDE AND EITHER A 4-BENZOYLISOXAZOLE OR A 2-CYANO-1,3-DIONE HERBICIDE; FOR EXAMPLE, TEBUTHIURON AND ISOXAFLUTOLE ON CEREAL OR SUGAR CANE CROPS RHONE-POULENC AGRO (FR) 2004-03-30 US disclosed
EP-1032267-B1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS BAYER CROPSCIENCE SA (FR) 2004-03-10 EP disclosed
US-20030060368-A1 Control of weeds using a synergistic mixture of a urea herbicide and either a 4-benzoylisoxazole or a 2-cyano-1,3-dione herbicide; for example, tebuthiuron and isoxaflutole on cereal or sugar cane crops MILLET JEAN-CLAUDE (FR) 2003-03-27 US disclosed
US-20010016560-A1 Herbicidal compositions MILLET JEAN-CLAUDE (FR) 2001-08-23 US disclosed
US-6214770-B1 UREA AND SULFONYLUREA HERBICIDES RHONE-POULENC AGRO (FR) 2001-04-10 US disclosed
EP-1032267-A1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS AVENTIS CROPSCIENCE S.A. (FR) 2000-09-06 EP disclosed
US-6069115-A BY A SINGLE POST-EMERGENT APPLICATION OF A GLYPHOSATE HERBICIDE, AND A GIVEN DERIVATIVES OF P-HYDROXYPHENYLPYRUVATE DIOXYGENASE(HPPD)-INHIBITING HERBICIDES TO GLYPHOSATE TOLERANT CROPS RHONE-POULENC AGROCHIMIE (FR) 2000-05-30 US disclosed
WO-1999023886-A1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS AVENTIS CROPSCIENCE S.A. (FR) 1999-05-20 WO disclosed
US-5804532-A REACTING A BENZOYL ISOXAZOLE WITH A BASE RHONE-POULENC AGRICULTURE LIMITED (GB) 1998-09-08 US disclosed
EP-0496630-B1 2-Cyano-1,3-dione herbicides RHONE POULENC AGRICULTURE (GB) 1995-06-07 EP disclosed
EP-0496630-A1 2-Cyano-1,3-dione herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1992-07-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030060368-A1 Control of weeds using a synergistic mixture of a urea herbicide and either a 4-benzoylisoxazole or a 2-cyano-1,3-dione herbicide; for example, tebuthiuron and isoxaflutole on cereal or sugar cane crops WEE1, GYS1, NOTUM LMNA 3885/4885MAPT 1357/4885GAA 143/4885
US-20010016560-A1 Herbicidal compositions DDT, IDUA, CYP4X1 LMNA 3543/4885MAPT 2567/4885GAA 368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.