SCHEMBL1740206

SCHEMBL1740206

CS(=O)(=O)c1cc(Cl)ccc1C(=O)C(C#N)C(=O)C1CC1

nearest known ligand 0.71

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.37
CNR1 P21554 1/20 0.36
TYK2 P29597 2/20 0.35
NPSR1 Q6W5P4 2/20 0.34
ALDH1A1 P00352 2/20 0.34
HTT P42858 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KMT2A Q03164 1/20 0.33
AVPR2 P30518 1/20 0.33
GPR27 Q9NS67 1/20 0.33
KDM4E B2RXH2 1/20 0.32
CNR2 P34972 1/20 0.32
GABRA1 P14867 3/20 0.32
GABRG2 P18507 3/20 0.32
GABRB3 P28472 3/20 0.32
GABRB2 P47870 2/20 0.32
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29355315 1.00 F10 (0.37) F10CNR1TYK2NPSR1ALDH1A1
SCHEMBL8606856 0.87 NR1I2 (0.32) KMT2A
SCHEMBL8196089 0.86 WDR5 (0.33)
SCHEMBL8606265 0.84 CNR1 (0.39) CNR1HTTKMT2A
SCHEMBL3950084 0.84 TSHR (0.32) ALDH1A1SMN1; SMN2KDM4E
SCHEMBL29355292 0.83 CACNA1B (0.45) TYK2ALDH1A1KDM4E
SCHEMBL8031405 0.83 NR1I2 (0.33)
SCHEMBL1071604 0.83 CACNA1B (0.45) TYK2ALDH1A1KDM4E
SCHEMBL18422535 0.83 CACNA1B (0.45) TYK2ALDH1A1KDM4E
SCHEMBL8605907 0.83 BCAT2 (0.40) TYK2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6713434-B2 CONTROL OF WEEDS USING A SYNERGISTIC MIXTURE OF A UREA HERBICIDE AND EITHER A 4-BENZOYLISOXAZOLE OR A 2-CYANO-1,3-DIONE HERBICIDE; FOR EXAMPLE, TEBUTHIURON AND ISOXAFLUTOLE ON CEREAL OR SUGAR CANE CROPS RHONE-POULENC AGRO (FR) 2004-03-30 US claimed
EP-1032267-B1 METHOD OF CONTROLLING WEEDS IN TRANSGENIC CROPS BAYER CROPSCIENCE SA (FR) 2004-03-10 EP claimed
US-20030060368-A1 Control of weeds using a synergistic mixture of a urea herbicide and either a 4-benzoylisoxazole or a 2-cyano-1,3-dione herbicide; for example, tebuthiuron and isoxaflutole on cereal or sugar cane crops MILLET JEAN-CLAUDE (FR) 2003-03-27 US claimed
US-20010016560-A1 Herbicidal compositions MILLET JEAN-CLAUDE (FR) 2001-08-23 US claimed
US-6069115-A BY A SINGLE POST-EMERGENT APPLICATION OF A GLYPHOSATE HERBICIDE, AND A GIVEN DERIVATIVES OF P-HYDROXYPHENYLPYRUVATE DIOXYGENASE(HPPD)-INHIBITING HERBICIDES TO GLYPHOSATE TOLERANT CROPS RHONE-POULENC AGROCHIMIE (FR) 2000-05-30 US claimed
EP-0880317-B1 STABLE HERBICIDAL COMPOSITIONS CONTAINING METAL CHELATES OF HERBICIDAL DIONE COMPOUNDS ZENECA LTD (GB) 2000-01-05 EP claimed
US-5912207-A HEAT STABLE, CHEMICALLY STABLE HERBICIDES ZENECA LIMITED (GB) 1999-06-15 US claimed
EP-0880317-A1 STABLE HERBICIDAL COMPOSITIONS CONTAINING METAL CHELATES OF HERBICIDAL DIONE COMPOUNDS ZENECA LIMITED (GB) 1998-12-02 EP claimed
WO-1997027748-A1 STABLE HERBICIDAL COMPOSITIONS CONTAINING METAL CHELATES OF HERBICIDAL DIONE COMPOUNDS ZENECA LIMITED (GB) 1997-08-07 WO claimed
EP-0496631-B1 2-Cyano-1,3-dione herbicides RHONE POULENC AGRICULTURE (GB) 1995-06-07 EP claimed
EP-0496631-A1 2-Cyano-1,3-dione herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1992-07-29 EP claimed
US-11230717-B2 Plants having increased tolerance to herbicides BASF SE (DE) 2022-01-25 US disclosed
US-11053514-B2 Soybean event SYHT0H2 and compositions and methods for detection thereof SYNGENTA PARTICIPATIONS AG (CH) 2021-07-06 US disclosed
US-11046971-B2 Plants having increased tolerance to herbicides BASF SE 2021-06-29 US disclosed
US-20210147866-A1 PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES BASF SE (DE) 2021-05-20 US disclosed
EP-0880317-A1 STABLE HERBICIDAL COMPOSITIONS CONTAINING METAL CHELATES OF HERBICIDAL DIONE COMPOUNDS ZENECA LIMITED (GB) 1998-12-02 EP disclosed
US-5804532-A REACTING A BENZOYL ISOXAZOLE WITH A BASE RHONE-POULENC AGRICULTURE LIMITED (GB) 1998-09-08 US disclosed
WO-1997027748-A1 STABLE HERBICIDAL COMPOSITIONS CONTAINING METAL CHELATES OF HERBICIDAL DIONE COMPOUNDS ZENECA LIMITED (GB) 1997-08-07 WO disclosed
EP-0496631-B1 2-Cyano-1,3-dione herbicides RHONE POULENC AGRICULTURE (GB) 1995-06-07 EP disclosed
EP-0496631-A1 2-Cyano-1,3-dione herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1992-07-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11230717-B2 Plants having increased tolerance to herbicides HPD, MPST, DNTT F10 4606/4885CNR1 4615/4885TYK2 4267/4885
US-20030060368-A1 Control of weeds using a synergistic mixture of a urea herbicide and either a 4-benzoylisoxazole or a 2-cyano-1,3-dione herbicide; for example, tebuthiuron and isoxaflutole on cereal or sugar cane crops WEE1, GYS1, NOTUM F10 2769/4885CNR1 2190/4885TYK2 1816/4885
US-20210147866-A1 PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES HPD, PAH, ME3 F10 4781/4885CNR1 4496/4885TYK2 4074/4885
US-20010016560-A1 Herbicidal compositions DDT, IDUA, CYP4X1 F10 4602/4885CNR1 1734/4885TYK2 3623/4885
US-11046971-B2 Plants having increased tolerance to herbicides HPD, MPST, DNTT F10 4606/4885CNR1 4615/4885TYK2 4267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.