Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mercaptopurine Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.58 |
| ▸ | F3 | P13726 | 1/20 | 0.58 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.58 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.58 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.58 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hypoxanthine SCHEMBL472854 | 0.86 | F7 (0.61) | F7F3SARM1SIRT2SIRT6 | |
| Thioguanine SCHEMBL2314990 | 0.86 | F7 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL2564210 | 0.82 | PI4KA (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL15700 | 0.82 | PI4KA (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL22748487 | 0.82 | PI4KA (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL23531102 | 0.81 | PI4KA (0.54) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL11807683 | 0.81 | PI4KA (0.54) | F7F3SARM1SIRT2SIRT6 | |
| Mercaptopurine Anhydrous SCHEMBL14125533 | 0.81 | F7 (0.54) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL7712108 | 0.81 | PI4KA (0.54) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL1324561 | 0.81 | PI4KA (0.54) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214789-A1 | Therapeutics | POTTER BARRY V L (GB) | 2004-10-28 | — | — | US | claimed |
| EP-1395267-A2 | THERAPEUTIC COMPOSITIONS FOR MODULATING THE IMMUNE RESPONSE IN A MAMMAL AND USE THEREOF | UNIVERSITY OF BATH (GB) | 2004-03-10 | — | — | EP | claimed |
| WO-2002098397-A2 | THERAPEUTIC COMPOSITIONS FOR MODULATING THE IMMUNE RESPONSE IN A MAMMAL AND USE THEREOF | UNIVERSITY OF BATH (GB) | 2002-12-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214789-A1 | Therapeutics | CD38, ADCY1, ADCY2 | F7 2667/4885F3 3270/4885SARM1 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.