Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 1/20 | 0.61 |
| ▸ | F3 | P13726 | 1/20 | 0.61 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hypoxanthine SCHEMBL9150757 | 0.91 | SIRT2 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Hypoxanthine SCHEMBL4083911 | 0.88 | ALDH1A1 (0.49) | F7F3SARM1SIRT2SIRT6 | |
| Mercaptopurine Anhydrous SCHEMBL6558420 | 0.86 | F7 (0.58) | F7F3SARM1SIRT2SIRT6 | |
| Guanine SCHEMBL1266684 | 0.86 | PNP (0.60) | F7F3SARM1SIRT2SIRT6 | |
| Hypoxanthine SCHEMBL1614959 | 0.86 | ALDH1A1 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Niacinamide SCHEMBL6558759 | 0.85 | F7 (0.50) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL15700 | 0.84 | PI4KA (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL22748487 | 0.84 | PI4KA (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL2564210 | 0.84 | PI4KA (0.55) | F7F3SARM1SIRT2SIRT6 | |
| Adenine SCHEMBL23531102 | 0.83 | PI4KA (0.54) | F7F3SARM1SIRT2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238264-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | DISARM THERAPEUTICS, INC. | 2024-07-18 | — | — | US | claimed |
| WO-2023077166-A1 | METHODS AND COMPOSITIONS FOR ANALYTE QUANTIFICATION | MATTERWORKS INC (US) | 2023-05-04 | — | — | WO | claimed |
| US-20230137741-A1 | METHODS AND COMPOSITIONS FOR ANALYTE QUANTIFICATION | MATTERWORKS INC | 2023-05-04 | — | — | US | claimed |
| US-20200129493-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | WASHINGTON UNIVERSITY (US) | 2020-04-30 | — | — | US | claimed |
| CN-110545804-A | SARM1 NAD enzyme activity inhibitor and application thereof | UNIV WASHINGTON | 2019-12-06 | — | — | CN | claimed |
| EP-3515426-A1 | INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF | Washington University (US) | 2019-07-31 | — | — | EP | claimed |
| WO-2018057989-A1 | INHIBITORS OF SARM1 NADase ACTIVITY AND USES THEREOF | WASHINGTON UNIVERSITY (US) | 2018-03-29 | — | — | WO | claimed |
| WO-2017114796-A1 | ADENOSYLHOMOCYSTEINASE BINDING SUBSTANCES FOR MEDICAL USE | LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN (DE) | 2017-07-06 | — | — | WO | claimed |
| EP-3187180-A1 | ADENOSYLHOMOCYSTEINASE BINDING SUBSTANCES FOR MEDICAL USE | Ludwig-Maximilians-Universität München (DE) | 2017-07-05 | — | — | EP | claimed |
| EP-2062979-B1 | Method for measuring phosphoric acid | NITTO BOSEKI CO LTD (JP) | 2015-11-11 | — | — | EP | claimed |
| EP-0639646-A1 | HIGH PRECISION DETERMINATION OF D-GLUCOSE-6-PHOSPHATE AND COMPOSITION THEREFOR | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1995-02-22 | — | — | EP | claimed |
| EP-0632133-A1 | HIGHLY SENSITIVE DETERMINATION OF D-3-HYDROXYBUTYRIC ACID OR ACETOACETIC ACID AND COMPOSITION THEREFOR | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-01-04 | — | — | EP | claimed |
| EP-0351774-B1 | Determination of blood ammonia levels | ABBOTT LAB (US) | 1994-09-28 | — | — | EP | claimed |
| US-5286627-A | Reacting with a steroid dehydrogenase; NAPD or NAD as a coenzyme | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1994-02-15 | — | — | US | claimed |
| US-5266463-A | Highly sensitive assay method for L-carnitine and composition for practicing same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1993-11-30 | — | — | US | claimed |
| US-5141853-A | Glutamate dehydrogenase, alpha-ketoglutarate and nicrotinamide hypoxanthine dinucleotide phosphate | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | claimed |
| EP-0477001-A2 | Highly sensitive assay method for myo-inositol and composition for practicing same | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1992-03-25 | — | — | EP | claimed |
| EP-0437373-A1 | High sensitive assay method of L-carnitine and composition for an assay | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1991-07-17 | — | — | EP | claimed |
| EP-0393624-A2 | Method of high-sensitive analysis of bile acid and reagent composition for the analysis | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1990-10-24 | — | — | EP | claimed |
| EP-0351774-A2 | Determination of blood ammonia levels | ABBOTT LABORATORIES (US) | 1990-01-24 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200129493-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | SARM1, NADK, NNMT | F7 4801/4885F3 4145/4885SARM1 1/4885 |
| US-20240238264-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | SARM1, NADK, NNMT | F7 4801/4885F3 4145/4885SARM1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.