Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 3/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16256979 | 0.83 | KCNE1 (0.36) | KCNE1KCNQ1SLC6A2SLC6A4MTNR1A | |
| SCHEMBL6559387 | 0.83 | KCNE1 (0.51) | KCNE1KCNQ1RORCTRPV1BRD4 | |
| SCHEMBL6558722 | 0.80 | KCNE1 (0.48) | KCNE1KCNQ1TRPV1 | |
| SCHEMBL6340401 | 0.77 | RORC (0.35) | KCNE1KCNQ1RORC | |
| SCHEMBL6338888 | 0.76 | SLC6A2 (0.35) | KCNE1KCNQ1SLC6A2SLC6A4KCNH2 | |
| SCHEMBL11932515 | 0.71 | RORC (0.34) | RORCSLC6A2SLC6A4SLC6A3TRPV1 | |
| SCHEMBL6559250 | 0.71 | KCNE1 (0.44) | KCNE1KCNQ1KCNH2TRPV1 | |
| SCHEMBL7470195 | 0.70 | KCNE1 (0.46) | KCNE1KCNQ1TRPV1 | |
| SCHEMBL6559963 | 0.69 | TRPV1 (0.42) | TRPV1 | |
| SCHEMBL6558702 | 0.69 | KCNE1 (0.40) | KCNE1KCNQ1KCNH2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |