Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL6560721 | 0.91 | LMNA (0.58) | LTA4HLMNAGPR88CHRNB2CHRNB4 | |
| SCHEMBL1253462 | 0.86 | LTA4H (0.61) | LTA4HLMNAGPR88CHRNB2CHRNB4 | |
| SCHEMBL6558981 | 0.86 | LMNA (0.54) | LTA4HLMNAGPR88CHRNB2CHRNB4 | |
| Phenoxyethanol SCHEMBL28149741 | 0.85 | ALDH1A1 (0.73) | LTA4HLMNACHRNB2CHRNB4CHRNA3 | |
| Ethylene Glycol SCHEMBL6558283 | 0.85 | LTA4H (0.74) | LTA4HLMNAMLNRNR1I2ESR1 | |
| Diphenylether SCHEMBL20590366 | 0.85 | LTA4H (0.59) | LTA4HLMNAGPR88ALDH1A1RECQL | |
| Methyl Alcohol SCHEMBL27471432 | 0.85 | LTA4H (0.80) | LTA4HLMNAMLNRNR1I2ESR1 | |
| SCHEMBL1331014 | 0.84 | LTA4H (0.87) | LTA4HLMNACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL36192 | 0.84 | LTA4H (0.87) | LTA4HLMNACHRNB2CHRNB4CHRNA3 | |
| Benzene SCHEMBL28132981 | 0.84 | LTA4H (0.87) | LTA4HLMNACHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5334255-A | Trapping particles by aqueous flood sheet consists of aprotic heterocyclic oxygenate, organic solvent and water; separation, collection, recycling, and distillation | BASF CORPORATION (US) | 1994-08-02 | — | — | US | claimed |
| CN-110204974-A | A kind of heat-insulation and heat-preservation sound-absorbing imitation stone lacquer of degradable formaldehyde and preparation method thereof | 阜阳师范学院 | 2019-09-06 | — | — | CN | disclosed |
| EP-0735403-B1 | Liquid crystal orienting agent | JSR CORP (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-5700860-A | Liquid crystal orienting agent | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1997-12-23 | — | — | US | disclosed |
| US-5641361-A | CONTACTING WITH FLOWING AQUEOUS FLOOD SHEET CONTAINING N-METHYLPYRROLIDONE, AN ALKYL GLYCOL ETHER AND A NONIONIC SURFACTANT | BASF CORPORATION (US) | 1997-06-24 | — | — | US | disclosed |
| EP-0598257-B1 | Use of a composition for reclaiming paint from a spray booth | BASF CORP (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0735403-A1 | Liquid crystal orienting agent | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5560860-A | RECIRCULATING HYDROPHILIC BASED FLUIDS | BASF CORPORATION (US) | 1996-10-01 | — | — | US | disclosed |
| US-5466300-A | Entrainment uncured overspraying paint particles in streams | BASF CORPORATION (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0431429-B1 | Process and composition used to reclaim paint from spray booth with a flood sheet system | BASF CORP (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5334255-A | Trapping particles by aqueous flood sheet consists of aprotic heterocyclic oxygenate, organic solvent and water; separation, collection, recycling, and distillation | BASF CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0598257-A1 | Composition for reclaiming paint from a spray booth | BASF CORPORATION (US) | 1994-05-25 | — | — | EP | disclosed |
| EP-0431429-A2 | Process and composition used to reclaim paint from spray booth with a flood sheet system | BASF Corporation (US) | 1991-06-12 | — | — | EP | disclosed |