Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL28932508 | 0.87 | LTA4H (0.47) | LTA4HTSHRRECQLALDH1A1HDAC3 | |
| Diphenylether SCHEMBL8373541 | 0.87 | LTA4H (0.49) | LTA4HTSHRRECQLMAPTHTT | |
| Diphenylether SCHEMBL20163306 | 0.86 | LTA4H (0.67) | LTA4HTSHRRECQLMAPTHTT | |
| Diphenylether SCHEMBL8929848 | 0.86 | LTA4H (0.77) | LTA4HTSHRRECQLMAPTHTT | |
| Diphenylether SCHEMBL7865304 | 0.85 | LMNA (0.47) | LTA4HTSHRRECQLALDH1A1LMNA | |
| Propylene Glycol SCHEMBL6558871 | 0.85 | LTA4H (0.65) | LTA4HRECQLHTTALDH1A1LMNA | |
| Diphenylether SCHEMBL8049569 | 0.84 | LMNA (0.53) | LTA4HTSHRLMNANPY5RKDM4E | |
| Diphenylether SCHEMBL28278306 | 0.84 | LTA4H (0.74) | LTA4HTSHRRECQLMAPTHTT | |
| Diphenylether SCHEMBL50452 | 0.84 | LMNA (0.57) | LTA4HTSHRMAPTHTTALDH1A1 | |
| Diphenylether SCHEMBL28057554 | 0.83 | LTA4H (0.62) | LTA4HTSHRRECQLMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3417017-A1 | LOW-EMISSION LIQUID FILM FOR SEALING BUILDINGS | Sika Technology AG (CH) | 2018-12-26 | — | — | EP | disclosed |