Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 16/20 | 0.86 |
| ▸ | MTNR1A | P48039 | 15/20 | 0.86 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559881 | 0.93 | MTNR1B (1.00) | MTNR1BMTNR1AHTR2CHTR2B | |
| SCHEMBL6560437 | 0.82 | MTNR1A (0.60) | MTNR1BMTNR1AHTR2CHTR2B | |
| SCHEMBL6559038 | 0.81 | MTNR1A (1.00) | MTNR1BMTNR1A | |
| SCHEMBL20542004 | 0.81 | MTNR1A (0.63) | MTNR1BMTNR1A | |
| SCHEMBL6558990 | 0.79 | MTNR1A (0.75) | MTNR1BMTNR1A | |
| SCHEMBL592246 | 0.79 | MTNR1A (0.67) | MTNR1BMTNR1A | |
| SCHEMBL30449211 | 0.78 | MTNR1A (0.73) | MTNR1BMTNR1AHTR2CHTR2B | |
| SCHEMBL29032157 | 0.78 | MTNR1A (0.73) | MTNR1BMTNR1AHTR2CHTR2B | |
| SCHEMBL6560401 | 0.78 | MTNR1A (0.74) | MTNR1BMTNR1A | |
| SCHEMBL8031017 | 0.78 | MTNR1A (0.86) | MTNR1BMTNR1AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837850-B1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-09-01 | — | — | EP | disclosed |
| EP-0837850-A1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5708005-A | MELATONIN RECEPTOR BINDERS, SLEEP DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| WO-1997001539-A1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-16 | — | — | WO | disclosed |