Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 15/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558999 | 0.94 | MTNR1A (0.67) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL6559728 | 0.83 | MTNR1A (0.69) | MTNR1AMTNR1B | |
| SCHEMBL6559028 | 0.82 | MTNR1B (0.86) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL6561400 | 0.81 | MTNR1A (0.69) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL6559737 | 0.81 | MTNR1A (0.63) | MTNR1AMTNR1B | |
| SCHEMBL29032149 | 0.80 | MTNR1A (0.58) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL6559745 | 0.80 | MTNR1A (0.64) | MTNR1AMTNR1B | |
| SCHEMBL6559877 | 0.77 | HTR6 (0.49) | HTR2C | |
| SCHEMBL8031017 | 0.77 | MTNR1A (0.86) | MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL30449419 | 0.76 | MTNR1A (0.67) | MTNR1AMTNR1BHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0837850-B1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-09-01 | — | — | EP | disclosed |
| EP-0837850-A1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5708005-A | MELATONIN RECEPTOR BINDERS, SLEEP DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| WO-1997001539-A1 | 4-ACYLAMINO(HALOGENO) ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-16 | — | — | WO | disclosed |