Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | METAP1 | P53582 | 3/20 | 0.42 |
| ▸ | BACE1 | P56817 | 10/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558578 | 0.91 | METAP2 (0.44) | METAP2METAP1BACE1SCN9A | |
| SCHEMBL6558573 | 0.91 | METAP2 (0.44) | METAP2METAP1BACE1SCN9A | |
| SCHEMBL6558490 | 0.91 | BACE1 (0.49) | METAP2METAP1BACE1BACE2ERAP2 | |
| SCHEMBL6559229 | 0.90 | METAP2 (0.45) | METAP2METAP1BACE1BACE2SCN9A | |
| Hydrochloric Acid SCHEMBL6560796 | 0.90 | METAP2 (0.43) | METAP2METAP1BACE1BACE2REN | |
| SCHEMBL6558478 | 0.89 | METAP2 (0.42) | METAP2METAP1BACE1BACE2REN | |
| SCHEMBL6559296 | 0.89 | BACE1 (0.44) | METAP2METAP1BACE1BACE2PSMB1 | |
| SCHEMBL6560842 | 0.89 | METAP2 (0.43) | METAP2METAP1BACE1BACE2SCN9A | |
| Hydrochloric Acid SCHEMBL6559317 | 0.88 | REN (0.43) | METAP2METAP1BACE1BACE2REN | |
| SCHEMBL6558505 | 0.88 | METAP2 (0.46) | METAP2METAP1BACE1BACE2ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998488-B1 | POLYOL-AMINO ACID COMPOUNDS HAVING ANTI-HELICOBACTER PYLORI ACTIVITY | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-03-17 | — | — | EP | disclosed |
| US-6423869-B1 | BACTERICIDES, ANTIULCER AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-07-23 | — | — | US | disclosed |