SCHEMBL6559724

SCHEMBL6559724

Cc1nc(-c2ccccc2)nn1-c1ccccc1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.47
CCNE1 P24864 1/20 0.46
CDK2 P24941 1/20 0.46
NR1H2 P55055 3/20 0.45
NR1H3 Q13133 3/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
ADORA1 P30542 4/20 0.43
POLB P06746 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPT P10636 1/20 0.42
XBP1 P17861 1/20 0.42
MAPK1 P28482 1/20 0.42
ADORA3 P0DMS8 3/20 0.42
KDM4A O75164 1/20 0.42
ADORA2A P29274 1/20 0.41
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14118409 0.83 ALDH1A1 (0.50) GAANR1H2NR1H3NPC1RAB9A
SCHEMBL14007393 0.78 NPC1 (0.52) NR1H2NR1H3NPC1RAB9AKDM4A
SCHEMBL6561418 0.73 BRD4 (0.49) GAANR1H3NPC1RAB9AADORA1
SCHEMBL14210107 0.71 NPC1 (0.45) NR1H2NR1H3NPC1RAB9AALDH1A1
SCHEMBL6560962 0.71 KDM4A (0.74) GAAKDM4EMAPTKDM4AALDH1A1
SCHEMBL13789915 0.71 GAA (0.50) GAACCNE1CDK2NPC1RAB9A
SCHEMBL7803874 0.70 ADORA1 (0.36) NR1H2NR1H3NPC1RAB9AADORA1
SCHEMBL6561450 0.70 HTR7 (0.50) ADORA1POLBKDM4EMAPTALDH1A1
SCHEMBL18952840 0.70 NR1H3 (0.48) NR1H2NR1H3NPC1RAB9APOLB
SCHEMBL16202035 0.70 NR1H3 (0.71) GAANR1H2NR1H3NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1071670-B1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA (DE) 2004-07-07 EP disclosed
US-6255327-B1 ANTIHYPOXC, ANTIISCHEMIC AGENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-07-03 US disclosed
EP-1071670-A1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM KG (DE) 2001-01-31 EP disclosed
WO-1999054314-A1 NOVEL DIPHENYL-SUBSTITUTED 5-RING-HETEROCYCLES, METHOD FOR PRODUCING THEM AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-10-28 WO disclosed