Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560815 | 0.83 | TRPV1 (0.48) | TRPV1KCNE1KCNQ1 | |
| SCHEMBL6559509 | 0.82 | TRPV1 (0.45) | TRPV1KCNE1KCNQ1DRD2HTR2A | |
| SCHEMBL6558679 | 0.79 | HPGD (0.41) | TRPV1ALDH1A1 | |
| SCHEMBL10583842 | 0.77 | FFAR4 (0.56) | TRPV1KMT2AALDH1A1TP53 | |
| SCHEMBL10589777 | 0.76 | APP (0.44) | TRPV1DRD2HTR2ADRD3ALDH1A1 | |
| SCHEMBL10589397 | 0.76 | APP (0.44) | TRPV1ALDH1A1 | |
| SCHEMBL10587463 | 0.75 | KCNA5 (0.52) | TRPV1 | |
| SCHEMBL10584290 | 0.75 | ALDH1A1 (0.44) | TRPV1KMT2AALDH1A1TP53 | |
| SCHEMBL10589903 | 0.74 | PSEN1 (0.46) | TRPV1DRD2HTR2AKMT2A | |
| SCHEMBL10587771 | 0.74 | ABCC9 (0.49) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |