Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6557537 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL6230011 | 0.72 | METAP1 (0.33) | METAP1MEN1MAPTKMT2A | |
| SCHEMBL18261221 | 0.69 | METAP1 (0.46) | METAP1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL6557768 | 0.68 | PGR (0.37) | — | |
| Hydrochloric Acid SCHEMBL5355300 | 0.67 | PGR (0.41) | MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL28112705 | 0.67 | METAP1 (0.41) | METAP1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL3273192 | 0.67 | METAP1 (0.41) | METAP1MEN1MAPTKMT2A | |
| Bromide SCHEMBL22228417 | 0.66 | PGR (0.37) | — | |
| Fluoride Ion SCHEMBL22228415 | 0.66 | PGR (0.37) | — | |
| Iodide SCHEMBL7930663 | 0.66 | PGR (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705851-B9 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-08-11 | — | — | EP | disclosed |
| EP-0705851-B1 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | CONOCOPHILLIPS CO (US) | 2004-01-21 | — | — | EP | disclosed |
| US-5594078-A | BRIDGED FLUORENYL METALLOCENE CATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5534473-A | METALLOCENES AND COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0705851-A2 | Catalyst systems and process for producing broad molecular weight distribution polyolefin | PHILLIPS PETROLEUM COMPANY (US) | 1996-04-10 | — | — | EP | disclosed |