Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 5/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.42 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.40 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6559957 | 0.89 | KCNE1 (0.50) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6558723 | 0.88 | KCNE1 (0.63) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6561024 | 0.87 | KCNE1 (0.48) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6558706 | 0.84 | KCNE1 (0.66) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6602008 | 0.81 | KCNE1 (0.44) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6559889 | 0.81 | KCNE1 (0.54) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9529230 | 0.81 | KDM4E (0.54) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6560005 | 0.80 | KCNE1 (0.43) | KCNE1KCNQ1MEN1KMT2A | |
| SCHEMBL6559311 | 0.78 | KCNE1 (0.52) | KCNE1KCNQ1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6560808 | 0.78 | KCNE1 (0.41) | KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807629-B1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| US-6191164-B1 | POTASSIUM CHANNEL MODULATORS; ANTIULCER AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0807629-A1 | Sulfonamido substituted chromane derivatives, method for their preparation, their use as medicaments or diagnostic agents aswell as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-11-19 | — | — | EP | disclosed |