Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 13/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735881 | 1.00 | HCAR3 (0.57) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL6560146 | 1.00 | HCAR3 (0.57) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL6560128 | 1.00 | HCAR3 (0.57) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL1075935 | 0.86 | VCAM1 (0.53) | MEN1KMT2ALMNAPDK1 | |
| SCHEMBL1075938 | 0.86 | VCAM1 (0.53) | MEN1KMT2ALMNAPDK1 | |
| SCHEMBL29276459 | 0.84 | HCAR3 (0.52) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL4521169 | 0.82 | HCAR3 (0.50) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL7573511 | 0.82 | PDK1 (0.70) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL7598666 | 0.81 | MEN1 (0.50) | HCAR3CASP6TSHRMEN1KMT2A | |
| SCHEMBL23752094 | 0.81 | CASP6 (0.62) | HCAR3CASP6TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391454-A1 | Substituted benzamide compounds with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2004-02-25 | — | — | EP | disclosed |
| EP-1195372-A1 | N-heterocyclic substituted benzamide derivatives with antihypertensive activity | Mitsubishi Pharma Corporation (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-6156766-A | Benzamide compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2000-12-05 | — | — | US | disclosed |
| US-5958944-A | TREATMENT OF CIRCULATORY DISEASES IN CORONARY, CEREBRAL, RENAL AND PERIPHERAL ARTERIES, AS A THERAPEUTIC AGENT FOR HYPERTENSION, ANGINA PECTORIS, AND RENAL AND PERIPHERAL CIRCULATION DISORDER, ANTIASTHMATIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0757038-A1 | BENZAMIDE COMPOUND AND MEDICINAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |