Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558852 | 0.87 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL6558857 | 0.83 | ACHE (0.37) | SMN1; SMN2PKMLMNAMAPK1HTT | |
| SCHEMBL1001565 | 0.77 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL3396649 | 0.74 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL1836203 | 0.74 | KDM4E (0.56) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL6559486 | 0.74 | SMN1; SMN2 (0.39) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL3993627 | 0.73 | ACHE (0.43) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL2335965 | 0.73 | KDM4E (0.39) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| Water SCHEMBL4610904 | 0.72 | ACHE (0.43) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM | |
| SCHEMBL4848699 | 0.70 | LMNA (0.45) | KDM4ESMN1; SMN2ALDH1A1HPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432394-A1 | AGENT FOR COLORING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | claimed |
| WO-2003030846-A1 | AGENT FOR COLORING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | claimed |
| EP-1432394-A1 | AGENT FOR COLORING KERATIN FIBERS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003030846-A1 | AGENT FOR COLORING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-04-17 | — | — | WO | disclosed |