Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031530 | 0.87 | LPL (0.46) | LPLLIPGCHKAEGFRNPC1 | |
| SCHEMBL13405763 | 0.80 | LMNA (0.43) | LPLLIPGCHKAEGFRNPC1 | |
| SCHEMBL2910682 | 0.75 | LPL (0.49) | LPLLIPGCHKA | |
| SCHEMBL9419251 | 0.74 | TRPA1 (0.44) | LPLLIPGCHKAEGFRNPC1 | |
| SCHEMBL14371206 | 0.73 | TP53 (0.50) | NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL12140863 | 0.73 | LMNA (0.38) | CHKAEGFRNPC1CYP1A2CYP2C19 | |
| SCHEMBL28881449 | 0.73 | LPL (0.44) | LPLLIPGEGFRNPC1CYP1A2 | |
| SCHEMBL16572151 | 0.73 | CA1 (0.51) | LPLLIPG | |
| SCHEMBL12075581 | 0.72 | MAOB (0.44) | CYP1A2CYP2C19SMN1; SMN2LMNA | |
| SCHEMBL18866855 | 0.72 | TAAR1 (0.42) | CHKAEGFRNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010702-B1 | Process for preparing ortho-substituted aryl metal compounds and their conversion with electrophiles | MERCK PATENT GMBH (DE) | 2004-07-28 | — | — | EP | disclosed |
| EP-1010703-B1 | Process for preparing aryl metal compounds and their conversion with electrophiles | MERCK PATENT GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
| US-6420584-B1 | DEPROTONATION USING ALKYL- OR ARYLMETAL COMPOUNDS OR METAL HYDRIDES IN THE PRESENCE OF A CATALYTIC AMOUNT OF A SECONDARY METAL AMIDE. | MERCK PATENT GMBH (DE) | 2002-07-16 | — | — | US | disclosed |
| US-6207835-B1 | DEPROTONATION IN CONTINUOUS FLOW REACTOR | MERCK KGAA (DE) | 2001-03-27 | — | — | US | disclosed |
| EP-1010702-A2 | Process for preparing ortho-substituted aryl metal compounds and their conversion with electrophiles | MERCK PATENT GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-1010703-A2 | Process for preparing aryl metal compounds and their conversion with electrophiles | MERCK PATENT GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-0440082-B1 | Method for the conversion of fluorinated aromatic compounds using electrophiles | MERCK PATENT GMBH (DE) | 1998-04-15 | — | — | EP | disclosed |
| US-5262556-A | Alkylation or hydroxyalkylation by deprotonation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-11-16 | — | — | US | disclosed |
| EP-0440082-A2 | Method for the conversion of fluorinated aromatic compounds using electrophiles | MERCK PATENT GmbH (DE) | 1991-08-07 | — | — | EP | disclosed |