Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 2/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560893 | 0.87 | LPL (0.37) | LPLLIPGCHKAEGFRSMN1; SMN2 | |
| SCHEMBL2910682 | 0.87 | LPL (0.49) | LPLLIPGCHKARARBMPL | |
| SCHEMBL13405763 | 0.85 | LMNA (0.43) | LPLLIPGCHKAEGFRSMN1; SMN2 | |
| SCHEMBL28881449 | 0.85 | LPL (0.44) | LPLLIPGEGFRSMN1; SMN2NPC1 | |
| SCHEMBL16572151 | 0.84 | CA1 (0.51) | LPLLIPGALDH1A1RARBMPL | |
| SCHEMBL7764726 | 0.83 | LPL (0.53) | LPLLIPGEGFRLMNAMAPK14 | |
| SCHEMBL29950872 | 0.83 | LPL (0.53) | LPLLIPGEGFRLMNAMAPK14 | |
| SCHEMBL7789321 | 0.82 | LIPG (0.54) | LPLLIPGEGFRLMNAMAPK14 | |
| SCHEMBL7786816 | 0.82 | LIPG (0.54) | LPLLIPGEGFRLMNAMAPK14 | |
| SCHEMBL1460538 | 0.80 | ESR1 (0.38) | CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304036-B2 | 2, 5-selenophene derivatives and 2, 5-tellurophene derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-11-06 | — | — | US | disclosed |
| US-8304036-B2 | 2, 5-selenophene derivatives and 2, 5-tellurophene derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-11-06 | — | — | US | disclosed |
| US-8304036-B2 | 2, 5-selenophene derivatives and 2, 5-tellurophene derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20100216986-A1 | 2, 5-SELENOPHENE DERIVATIVES AND 2, 5-TELLUROPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216986-A1 | 2, 5-SELENOPHENE DERIVATIVES AND 2, 5-TELLUROPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216986-A1 | 2, 5-SELENOPHENE DERIVATIVES AND 2, 5-TELLUROPHENE DERIVATIVES | MERCK PATENT GESELLSCHAFT (DE) | 2010-08-26 | — | — | US | disclosed |
| WO-2009033532-A1 | 2,5-SELENOPHENE DERIVATIVES AND 2,5-TELLUROPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009033532-A1 | 2,5-SELENOPHENE DERIVATIVES AND 2,5-TELLUROPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-03-19 | — | — | WO | disclosed |
| US-6420584-B1 | DEPROTONATION USING ALKYL- OR ARYLMETAL COMPOUNDS OR METAL HYDRIDES IN THE PRESENCE OF A CATALYTIC AMOUNT OF A SECONDARY METAL AMIDE. | MERCK PATENT GMBH (DE) | 2002-07-16 | — | — | US | disclosed |
| US-6207835-B1 | DEPROTONATION IN CONTINUOUS FLOW REACTOR | MERCK KGAA (DE) | 2001-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216986-A1 | 2, 5-SELENOPHENE DERIVATIVES AND 2, 5-TELLUROPHENE DERIVATIVES | SELENOI, SCLY, SULT1E1 | LPL 3312/4885LIPG 2909/4885CHKA 4272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.