Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561211 | 0.93 | DRD2 (0.44) | DRD2DRD3DRD4KCNH2CRHR1 | |
| SCHEMBL6558758 | 0.81 | DRD2 (0.49) | DRD2DRD3DRD4KCNH2NFKB1 | |
| SCHEMBL6559415 | 0.75 | DRD2 (0.43) | DRD2DRD3DRD4NFKB1THPO | |
| SCHEMBL6558776 | 0.72 | DRD2 (0.54) | DRD2DRD3DRD4KCNH2 | |
| SCHEMBL6560089 | 0.68 | DRD2 (0.49) | DRD2DRD3DRD4KCNH2NFKB1 | |
| SCHEMBL6559628 | 0.67 | DRD2 (0.59) | DRD2DRD3DRD4KCNH2NFKB1 | |
| Propylamine SCHEMBL6560092 | 0.62 | MAPT (0.41) | DRD2DRD3DRD4KCNH2PLAU | |
| SCHEMBL6558780 | 0.60 | HTR1A (0.49) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL8794907 | 0.59 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL27814400 | 0.59 | HTR2A (0.42) | DRD3KCNH2HTR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |