Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067726 | 0.88 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL31527791 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL1051087 | 0.81 | LMNA (0.52) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL5360302 | 0.81 | LMNA (0.78) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL8666206 | 0.81 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL8869963 | 0.80 | LMNA (0.50) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL6806477 | 0.79 | LMNA (0.75) | SMN1; SMN2LMNAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL6744329 | 0.79 | LMNA (0.49) | SMN1; SMN2LMNAALDH1A1KMT2ACYP1A2 | |
| SCHEMBL9432383 | 0.77 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNATSHRALDH1A1KMT2A | |
| SCHEMBL9432808 | 0.77 | LMNA (0.70) | SMN1; SMN2LMNAALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108813-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-05-08 | — | — | US | disclosed |
| EP-0892786-B1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | ABBOTT GMBH & CO KG (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6670367-B1 | Vasodilator; hypertension; surprisingly show antagonistic action on the neurokinin receptor; 2-(4-Methoxy-6-methyl-2-pyrimidinyloxy)-3-(2-(3,4- dimethoxyphenyl)ethoxy)-3,3-diphenylpropionic Acid | ABBOTT GMBH & CO., KG (DE) | 2003-12-30 | — | — | US | disclosed |
| US-6610691-B1 | Inhibit binding of endothelin to receptor; treating hypertension | BASF AKTIENGESELLSCHAFT (DE) | 2003-08-26 | — | — | US | disclosed |
| US-6509341-B1 | The invention relates to carboxylic acid derivatives of formula (I), wherein the substituents have the meaning as commented in the description. It also relates to the production and use of same as endothelin receptor antagonists. | ABBOTT LABORATORIES | 2003-01-21 | — | — | US | disclosed |
| EP-0994861-A1 | NEW $g(b)-AMINO AND $g(b)-AZIDOCARBOXYLIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2000-04-26 | — | — | EP | disclosed |
| EP-0929529-A2 | AZINYLOXY, AND PHENOXY-DIARYL-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS MIXED ET A?/ET B? ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1999-07-21 | — | — | EP | disclosed |
| EP-0892786-A1 | NEW CARBOXYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1998058916-A1 | NEW β-AMINO AND β-AZIDOCARBOXYLIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-30 | — | — | WO | disclosed |
| WO-1998009953-A2 | AZINYLOXY-AND PHENOXY-DIARYL-CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS MIXED ETA/ETB ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 1998-03-12 | — | — | WO | disclosed |
| EP-0355385-B1 | SUBSTITUTED 4-SULPHONYLAMINO-2-AZINYL-1,2,4-TRIAZOL-3-ONES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AG (DE) | 1993-05-19 | — | — | EP | disclosed |
| EP-0532948-A1 | Substituted cycloalkenes as herbicides | BAYER AG (DE) | 1993-03-24 | — | — | EP | disclosed |
| US-5151514-A | Triazine substituted herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-29 | — | — | US | disclosed |
| US-5142060-A | Herbicidal substituted 4-sulphonylamino-2-azinyl-1,2,4-triazol-3-ones | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-25 | — | — | US | disclosed |
| US-5089627-A | Chemical intermediates therefor | BAYER AKTIENGESELLSCHAFT (DE) | 1992-02-18 | — | — | US | disclosed |
| US-5085687-A | HERBICIDAL SUBSTITUTED 4-SULPHONYLAMINO-2-AZINYL-1,2,4-TRIAZOL-3-ONES | BAYER AKTIENGESELLSCHAFT (DE) | 1992-02-04 | — | — | US | disclosed |
| US-4988381-A | HERBICIDES, PLANT GROWTH REGULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| EP-0355385-A1 | Substituted 4-sulphonylamino-2-azinyl-1,2,4-triazol-3-ones, process and intermediates for their preparation and their use as herbicides | BAYER AG (DE) | 1990-02-28 | — | — | EP | disclosed |
| US-4711959-A | REACTING 2-ALKYLSULPHONYL-PYRIMIDINE WITH CYANAMIDE OR METAL SALT OF CYANAMIDE | BAYER AKTIENGESELLSCHAFT (DE) | 1987-12-08 | — | — | US | disclosed |
| EP-0209779-A2 | Process for the preparation of 2-cyanaminopyrimidine derivatives | BAYER AG (DE) | 1987-01-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108813-A1 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | C1S, CYP2S1, SULT2A1 | SMN1; SMN2 2811/4885LMNA 2402/4885TSHR 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.