SCHEMBL6561770

SCHEMBL6561770

CCCc1cccc2c1c(OCCCSc1ccc(CC(=O)OC)cc1Cl)cn2CC

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 10/20 0.46
PPARG P37231 10/20 0.46
PPARA Q07869 9/20 0.46
NR1H2 P55055 1/20 0.43
NR1H3 Q13133 1/20 0.43
MAPT P10636 3/20 0.35
HPGD P15428 2/20 0.35
TSHR P16473 1/20 0.35
ALDH1A1 P00352 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
IL1B P01584 1/20 0.33
P2RX7 Q99572 1/20 0.33
MCL1 Q07820 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6561712 0.92 PPARD (0.55) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6559248 0.76 PPARD (0.39) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6937863 0.76 PPARD (0.55) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6934065 0.76 PPARD (0.58) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL5203913 0.76 PPARG (0.52) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL7042280 0.74 PPARG (0.65) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6936742 0.74 PPARG (0.60) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6933376 0.74 PPARG (0.57) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6936744 0.74 PPARG (0.60) PPARDPPARGPPARANR1H2NR1H3
SCHEMBL6936613 0.73 PPARG (0.70) PPARDPPARGPPARANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0904079-B1 ANTIDIABETIC AGENTS MERCK & CO INC (US) 2004-03-24 EP disclosed
EP-0904079-A4 1999-05-06 EP disclosed
EP-0904079-A1 ANTIDIABETIC AGENTS Merck & Co., Inc. (US) 1999-03-31 EP disclosed
US-5859051-A ACETYLPHENOL DERIVATIVES MERCK & CO., INC. (US) 1999-01-12 US disclosed
WO-1997027857-A1 ANTIDIABETIC AGENTS MERCK & CO., INC. (US) 1997-08-07 WO disclosed