Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 6/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 6/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 6/20 | 0.41 |
| ▸ | F10 | P00742 | 6/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566003 | 0.86 | F2 (0.37) | F2F10PRSS1NPC1ALDH1A1 | |
| SCHEMBL6563675 | 0.78 | F10 (0.47) | F10PRSS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6563450 | 0.77 | F10 (0.48) | F2F10PRSS1NPC1ALDH1A1 | |
| SCHEMBL6563662 | 0.77 | F10 (0.41) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6565941 | 0.76 | F10 (0.47) | F10PRSS1ALDH1A1 | |
| SCHEMBL7671074 | 0.76 | F10 (0.43) | F2F10PRSS1ALDH1A1PRSS2 | |
| SCHEMBL6561958 | 0.75 | ACACB (0.49) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6563220 | 0.75 | HPGD (0.44) | F10PRSS1LMNA | |
| SCHEMBL6565351 | 0.74 | F10 (0.44) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL6563597 | 0.72 | F10 (0.38) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |