Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562009 | 0.93 | GCK (0.48) | GCKLMNAMAPT | |
| SCHEMBL6560881 | 0.88 | FFAR2 (0.52) | GCK | |
| SCHEMBL6561909 | 0.87 | GCK (0.61) | GCK | |
| SCHEMBL6596857 | 0.86 | GCK (0.51) | GCK | |
| SCHEMBL2645677 | 0.86 | SMN1; SMN2 (0.53) | GCKALDH1A1 | |
| SCHEMBL2646191 | 0.85 | ALDH1A1 (0.57) | GCKLMNAALDH1A1MAPTCRHBP | |
| SCHEMBL2647038 | 0.85 | GCK (0.47) | GCK | |
| SCHEMBL2645498 | 0.82 | GCK (0.51) | GCKLMNAMAPT | |
| SCHEMBL6563294 | 0.82 | L3MBTL1 (0.41) | GCKLMNAMAPT | |
| SCHEMBL27480878 | 0.81 | GCK (0.52) | GCKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169312-B1 | GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2004-10-06 | — | — | EP | claimed |