Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562162 | 0.91 | KMT2A (0.53) | KMT2ANPC1RAB9ALMNAKDM4E | |
| Iodide SCHEMBL5949446 | 0.90 | KMT2A (0.52) | KMT2ANPC1RAB9ALMNAKDM4E | |
| SCHEMBL6345616 | 0.86 | NPC1 (0.42) | KMT2ANPC1RAB9ALMNAKDM4E | |
| SCHEMBL6342237 | 0.85 | MAPT (0.46) | KMT2ANPC1RAB9ALMNAKDM4E | |
| SCHEMBL6344200 | 0.85 | SMN1; SMN2 (0.40) | KMT2ANPC1RAB9ALMNAGSK3B | |
| SCHEMBL11619439 | 0.79 | KMT2A (0.52) | KMT2ANPC1RAB9ALMNAKDM4E | |
| SCHEMBL6352961 | 0.77 | L3MBTL1 (0.39) | KMT2ANPC1RAB9AKDM4EMAPT | |
| SCHEMBL6562435 | 0.76 | NPC1 (0.50) | KMT2ANPC1RAB9ALMNAKDM4E | |
| SCHEMBL6342168 | 0.75 | LMNA (0.42) | KMT2ANPC1RAB9ALMNAKDM4E | |
| SCHEMBL6561313 | 0.75 | CES2 (0.54) | KMT2ANPC1RAB9ALMNAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004168-A1 | New substituted pyridine or piperidine compounds | METH-COHN OTTO (GB) | 2005-01-06 | — | — | US | disclosed |
| US-20020040036-A1 | New substituted pyridine or piperidine compounds | ADIR ET COMPAGNIE | 2002-04-04 | — | — | US | disclosed |
| US-20020035123-A1 | New substituted pyridine or piperidine compounds | ADIR ET COMPAGNIE | 2002-03-21 | — | — | US | disclosed |
| US-6323220-B1 | COGNITION ACTIVATORS AND TREATMENT OF NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004168-A1 | New substituted pyridine or piperidine compounds | HRH3, HRH4, HRH1 | KMT2A 1973/4885NPC1 2766/4885RAB9A 990/4885 |
| US-20020035123-A1 | New substituted pyridine or piperidine compounds | OPRD1, CNR1, HRH4 | KMT2A 2175/4885NPC1 2642/4885RAB9A 1212/4885 |
| US-20020040036-A1 | New substituted pyridine or piperidine compounds | CNR1, OPRD1, OPRK1 | KMT2A 2442/4885NPC1 2469/4885RAB9A 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.