Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.70 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.70 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188850 | 0.81 | ALDH1A1 (0.47) | KEAP1NFE2L2HDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6560643 | 0.81 | KEAP1 (0.70) | KEAP1NFE2L2HDAC1ALDH1A1TP53 | |
| SCHEMBL28450939 | 0.80 | MEN1 (0.68) | KEAP1NFE2L2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28784798 | 0.80 | LMNA (0.68) | KEAP1NFE2L2CA12CA9ALDH1A1 | |
| SCHEMBL8752463 | 0.79 | CA12 (1.00) | KEAP1NFE2L2CA12CA9ALDH1A1 | |
| SCHEMBL11571224 | 0.79 | TSHR (0.60) | KEAP1NFE2L2CA12CA9ALDH1A1 | |
| SCHEMBL4192504 | 0.78 | TSHR (0.51) | KEAP1NFE2L2ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL4193381 | 0.78 | SMN1; SMN2 (0.70) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7591017 | 0.78 | KEAP1 (0.67) | KEAP1NFE2L2CA12CA9ALDH1A1 | |
| SCHEMBL5046592 | 0.77 | HDAC1 (1.00) | CA12CA9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990645-B1 | NOVEL SULFONAMIDE DERIVATIVES | NIPPON KAYAKU KK (JP) | 2004-07-28 | — | — | EP | disclosed |
| US-6458960-B1 | ANTICANCER AGENTS, RHEUMATIC DISEASES AND ANTIINFLAMMATORY AGENTS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2002-10-01 | — | — | US | disclosed |
| US-6180796-B1 | TUBULIN POLYMERIZATION INHIBITORS | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-01-30 | — | — | US | disclosed |
| EP-0990645-A1 | NOVEL SULFONAMIDE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-05 | — | — | EP | disclosed |