SCHEMBL6563225

SCHEMBL6563225

Cc1cccc(C#CCNc2ccc(C#N)cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.44
GRM5 P41594 4/20 0.40
MAPT P10636 3/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C19 P33261 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
MAPK1 P28482 1/20 0.39
HSD17B10 Q99714 1/20 0.39
VNN1 O95497 1/20 0.39
ALDH1A1 P00352 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP2A6 P11509 1/20 0.39
FFAR1 O14842 2/20 0.39
AR P10275 1/20 0.39
HTT P42858 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29712645 0.84 GRM5 (0.53) GRM5MAPTCYP1A2CYP3A4CYP2D6
SCHEMBL6565878 0.83 ABCG2 (0.42) GRM5CYP1A2CYP3A4CYP2C19TSHR
SCHEMBL6563265 0.83 ALDH1A1 (0.55) GRM5MAPTALDH1A1MEN1KMT2A
SCHEMBL6565292 0.79 KCNA5 (0.39) GRM5MAPTTSHRALDH1A1MEN1
SCHEMBL6563255 0.78 PRSS1 (0.44)
SCHEMBL28944597 0.78 GRM5 (0.47) GRM5CYP1A2CYP3A4CYP2C19KDM4E
SCHEMBL6565837 0.76 CYP1A1 (0.44) GRM5CYP1A2TSHRCYP11B2
SCHEMBL29712668 0.75 MAPT (0.55) GRM5MAPTCYP1A2CYP3A4CYP2D6
SCHEMBL9001796 0.73 ALDH1A1 (0.67) IDO1GRM5MAPTTSHRALDH1A1
SCHEMBL6563318 0.73 BCHE (0.49) IDO1MAPTALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140802-B1 SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES BOEHRINGER INGELHEIM PHARMA (DE) 2004-03-17 EP disclosed
US-6479524-B1 TO PROLONG THE THROMBIN TIME BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-11-12 US disclosed
EP-1140802-A1 SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES BOEHRINGER INGELHEIM KG (DE) 2001-10-10 EP disclosed
WO-2000035859-A1 SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-06-22 WO disclosed