Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.44 |
| ▸ | F2 | P00734 | 6/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | PLAU | P00749 | 3/20 | 0.42 |
| ▸ | PLAT | P00750 | 3/20 | 0.42 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | KLK1 | P06870 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563461 | 0.83 | PRSS1 (0.49) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7673744 | 0.81 | ASIC3 (0.40) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL29712645 | 0.80 | GRM5 (0.53) | — | |
| SCHEMBL7670899 | 0.78 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6563225 | 0.78 | IDO1 (0.44) | — | |
| SCHEMBL6563277 | 0.77 | F2 (0.41) | PRSS1F2F10PLAUPLAT | |
| SCHEMBL6561827 | 0.75 | MRGPRX1 (0.51) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6563625 | 0.75 | PRSS1 (0.43) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7669552 | 0.75 | HPN (0.45) | PRSS1PLAU | |
| SCHEMBL6562437 | 0.75 | KLK5 (0.47) | F10KLK1KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |