SCHEMBL6565292

SCHEMBL6565292

CN(c1ccccc1)c1cccc(C#CCNc2ccc(C#N)cc2)c1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 2/20 0.39
KCNN4 O15554 1/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
SCN9A Q15858 1/20 0.37
ABCG2 Q9UNQ0 4/20 0.37
GRM5 P41594 1/20 0.36
TSHR P16473 1/20 0.35
EGLN1 Q9GZT9 1/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
FFAR1 O14842 1/20 0.34
ABCB1 P08183 2/20 0.34
ABCC1 P33527 1/20 0.34
KDM1A O60341 1/20 0.34
NR3C2 P08235 1/20 0.34
KDM4C Q9H3R0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6565878 0.82 ABCG2 (0.42) ABCG2GRM5TSHRALDH1A1ABCB1
SCHEMBL7673744 0.81 ASIC3 (0.40)
SCHEMBL6563225 0.79 IDO1 (0.44) GRM5TSHRKMT2AMEN1ALDH1A1
SCHEMBL28944597 0.78 GRM5 (0.47) CRHBPCRHR2ABCG2GRM5TSHR
SCHEMBL12060550 0.78 KCNA5 (0.49) KCNA5KCNN4SCN9AABCG2GRM5
SCHEMBL7675442 0.78 CRHBP (0.50) CRHBPCRHR2KMT2AMEN1
SCHEMBL6563594 0.76 KMT2A (0.51) KMT2AMEN1ALDH1A1MAPT
SCHEMBL6565837 0.76 CYP1A1 (0.44) ABCG2GRM5TSHRABCB1ABCC1
SCHEMBL149439 0.72 TSHR (0.54) CRHBPCRHR2SCN9AABCG2TSHR
SCHEMBL12047766 0.72 KCNN4 (0.48) KCNA5KCNN4SCN9AABCG2GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140802-B1 SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES BOEHRINGER INGELHEIM PHARMA (DE) 2004-03-17 EP disclosed
US-6479524-B1 TO PROLONG THE THROMBIN TIME BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-11-12 US disclosed
EP-1140802-A1 SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES BOEHRINGER INGELHEIM KG (DE) 2001-10-10 EP disclosed
WO-2000035859-A1 SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-06-22 WO disclosed