Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6563409 | 0.98 | HTT (0.55) | HTTMEN1KMT2AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL6560410 | 0.85 | PTGS2 (0.43) | HTTMAPTALDH1A1ITGB1ITGA4 | |
| Hydrochloric Acid SCHEMBL6560412 | 0.81 | PTGS2 (0.41) | ALDH1A1ITGB1ITGA4SMO | |
| SCHEMBL6510240 | 0.81 | ITGB1 (0.48) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL28460065 | 0.79 | KDM4E (0.62) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6560946 | 0.79 | MAPT (0.49) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL18073562 | 0.77 | MEN1 (0.62) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4516203 | 0.77 | ITGB1 (0.57) | KMT2AITGB1ITGA4 | |
| SCHEMBL4516205 | 0.77 | ITGB1 (0.57) | KMT2AITGB1ITGA4 | |
| SCHEMBL7101344 | 0.77 | ITGB1 (0.57) | KMT2AITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144365-B1 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2004-03-17 | — | — | EP | disclosed |