Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510240 | 0.89 | ITGB1 (0.48) | MAPTMEN1KMT2ANPSR1ITGB1 | |
| SCHEMBL6563210 | 0.87 | MAPT (0.46) | MAPTKDM4ETDP1MEN1KMT2A | |
| SCHEMBL6561292 | 0.81 | ITGB1 (0.56) | ITGB1ITGA4ITGB3ITGAVITGA2B | |
| SCHEMBL14799578 | 0.81 | ITGB1 (0.56) | ITGB1ITGA4ITGB3ITGAVITGA2B | |
| SCHEMBL20715930 | 0.80 | ITGB3 (0.61) | MAPTKDM4ETDP1MEN1KMT2A | |
| SCHEMBL6642502 | 0.79 | GAA (0.48) | MAPTMEN1KMT2ANPSR1ITGB1 | |
| Hydrochloric Acid SCHEMBL6563409 | 0.79 | HTT (0.55) | MAPTKDM4EMEN1KMT2AITGB1 | |
| Hydrochloric Acid SCHEMBL6563404 | 0.79 | HTT (0.55) | MAPTKDM4EMEN1KMT2AITGB1 | |
| SCHEMBL7485965 | 0.79 | TSHR (0.55) | KMT2ANPSR1ITGB1ITGA4ITGB7 | |
| SCHEMBL6516319 | 0.79 | ITGA4 (0.59) | MAPTMEN1KMT2AITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144365-B1 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2004-03-17 | — | — | EP | disclosed |
| EP-1144365-A3 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2003-07-09 | — | — | EP | disclosed |
| EP-1144365-A2 | INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000037429-A2 | INHIBITORS OF α4β1 MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |