Sugi Predict

Sugi Predict / Compounds / SCHEMBL6563972

SCHEMBL6563972

SCHEMBL6563972

CC(C)(C)NS(=O)(=O)c1c(Cl)ccc(N)c1O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NSD2 O96028 2/20 0.42
▸ ALDH1A1 P00352 4/20 0.38
▸ JAK2 O60674 2/20 0.36
▸ HSP90AA1 P07900 1/20 0.36
▸ HSP90AB1 P08238 1/20 0.36
▸ SMN1; SMN2 Q16637 3/20 0.35
▸ MAPT P10636 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ CCR6 P51684 1/20 0.34
▸ THRB P10828 2/20 0.34
▸ RECQL P46063 2/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ ALOX15 P16050 1/20 0.34
▸ TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6550689 0.82 CA12 (0.39) ALDH1A1HSP90AA1HSP90AB1SMN1; SMN2HPGD
SCHEMBL17293511 0.79 CXCR2 (0.46) ALDH1A1HSP90AA1HSP90AB1HPGDNPC1
SCHEMBL6564160 0.78 ALDH1A1 (0.42) ALDH1A1HSP90AA1HSP90AB1HPGDLMNA
SCHEMBL6565765 0.78 VCAM1 (0.41) ALDH1A1HSP90AA1HSP90AB1SMN1; SMN2HPGD
SCHEMBL6564110 0.77 VCAM1 (0.43) ALDH1A1MAPTMEN1LMNAKMT2A
SCHEMBL14227577 0.76 ALDH1A1 (0.40) ALDH1A1HSP90AA1HSP90AB1HPGDLMNA
SCHEMBL19065988 0.76 CXCR2 (0.39) ALDH1A1HSP90AA1HSP90AB1HPGDMEN1
SCHEMBL17293393 0.76 CXCR2 (0.45) ALDH1A1HSP90AA1HSP90AB1HPGDMEN1
SCHEMBL6565726 0.76 CA12 (0.46) ALDH1A1HSP90AA1HSP90AB1SMN1; SMN2HPGD
SCHEMBL12932904 0.75 ALDH1A1 (0.42) NSD2ALDH1A1JAK2SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1161232-B1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2004-03-24 — — EP disclosed
US-20030109527-A1 Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION 2003-06-12 — — US disclosed
US-6500863-B1 INTERLEUKIN BINDING INHIBITORS SUCH AS N-(2-HYDROXYL-3-AMINO SULFONYL-4-CHLOROPHENYL)-N'-(2-BROMOPHENYL)UREA, USED FOR PROPHYLAXIS OF CHEMOKINE MEDIATED DISEASES SMITHKLINE BEECHAM CORPORATION 2002-12-31 — — US disclosed
EP-1161232-A4 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2002-09-18 — — EP disclosed
EP-1161232-A1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2001-12-12 — — EP disclosed
WO-2000035442-A1 HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030109527-A1 Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists CXCL8, CCR8, IL18 NSD2 3514/4885ALDH1A1 1321/4885JAK2 289/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.