Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 15/20 | 0.60 |
| ▸ | HSD17B2 | P37059 | 14/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27688659 | 0.84 | HDAC6 (0.57) | HSD17B1HSD17B2HDAC6 | |
| SCHEMBL3641638 | 0.81 | HSD17B1 (0.59) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL26681320 | 0.79 | HSD17B1 (0.56) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL13267656 | 0.75 | ALAD (0.66) | CYP2D6HDAC6 | |
| SCHEMBL27794744 | 0.75 | ALAD (0.66) | CYP2C9CYP2C19HDAC6 | |
| SCHEMBL13267782 | 0.74 | MMP12 (0.47) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7608519 | 0.73 | HSD17B1 (0.53) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL242998 | 0.72 | SMN1; SMN2 (0.56) | HSD17B1HSD17B2HDAC6 | |
| Propane SCHEMBL5843489 | 0.72 | HSD17B1 (0.71) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL30186296 | 0.72 | HSD17B1 (0.65) | HSD17B1HSD17B2CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831106-B1 | Selective activity on cell proliferation and differentiation without displaying any hypercalcaemiant nature | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-12-14 | — | — | US | disclosed |
| EP-1235777-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2004-06-16 | — | — | EP | disclosed |