SCHEMBL6564051

SCHEMBL6564051

Cc1cc(Br)ccc1-c1cccc(OCc2ccc(C(O[SiH](C)C)C(C)(C)C)c(C(O[SiH](C)C)C(C)(C)C)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOB P27338 13/20 0.39
FFAR1 O14842 7/20 0.36
MAOA P21397 2/20 0.34
FFAR4 Q5NUL3 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6882532 0.86 FFAR1 (0.36) FFAR1FFAR4
SCHEMBL6888111 0.86 FFAR1 (0.36) FFAR1FFAR4
SCHEMBL6886435 0.85 RORC (0.36) MAOBFFAR1FFAR4
SCHEMBL6564726 0.77 MAOB (0.42) MAOBFFAR1MAOAFFAR4
SCHEMBL6566495 0.72 MAOB (0.46) MAOBFFAR1MAOAFFAR4
SCHEMBL6158466 0.71 NOS1 (0.37) MAOBFFAR1
SCHEMBL6564059 0.71 MAOB (0.40) MAOBFFAR1MAOAFFAR4
SCHEMBL6564056 0.71 MAOB (0.40) MAOBFFAR1MAOAFFAR4
SCHEMBL6565068 0.71 FFAR1 (0.49) MAOBFFAR1MAOAFFAR4
SCHEMBL6885404 0.70 CYSLTR2 (0.48) FFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6831106-B1 Selective activity on cell proliferation and differentiation without displaying any hypercalcaemiant nature GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2004-12-14 US disclosed
EP-1235777-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2004-06-16 EP disclosed
EP-1235777-A2 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2002-09-04 EP disclosed
WO-2001038303-A2 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2001-05-31 WO disclosed