SCHEMBL6885404

SCHEMBL6885404

C[SiH](C)OC(c1ccc(COc2cccc(CCCCC(=O)O)c2)cc1C(O[SiH](C)C)C(C)(C)C)C(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 1/20 0.48
CYSLTR1 Q9Y271 1/20 0.48
FFAR1 O14842 16/20 0.47
FFAR4 Q5NUL3 6/20 0.43
PPARA Q07869 2/20 0.42
PPARG P37231 1/20 0.42
AKR1B1 P15121 1/20 0.39
TSHR P16473 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6878841 0.91 HDAC1 (0.40) CYSLTR2CYSLTR1FFAR1PPARAPPARG
SCHEMBL6158466 0.87 NOS1 (0.37) CYSLTR2CYSLTR1FFAR1PPARAPPARG
SCHEMBL6885577 0.80 FFAR1 (0.43) FFAR1FFAR4
SCHEMBL4847215 0.73 CYSLTR2 (0.69) CYSLTR2CYSLTR1FFAR1FFAR4PPARA
SCHEMBL4392789 0.73 FFAR1 (0.64) CYSLTR2CYSLTR1FFAR1FFAR4AKR1B1
SCHEMBL5763262 0.72 FFAR1 (0.70) CYSLTR2CYSLTR1FFAR1FFAR4PPARA
SCHEMBL6156494 0.71 FFAR1 (0.48) CYSLTR2CYSLTR1FFAR1FFAR4PPARA
SCHEMBL6156487 0.71 CYSLTR2 (0.50) CYSLTR2CYSLTR1FFAR1FFAR4PPARA
SCHEMBL6878729 0.71 FFAR1 (0.37) FFAR1
SCHEMBL5871915 0.71 KDM4E (0.35) PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US disclosed