Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567309 | 0.84 | MRGPRX4 (0.50) | MRGPRX4HDAC6HDAC1HDAC8MEN1 | |
| SCHEMBL6567192 | 0.82 | MCHR1 (0.53) | MCHR1TLR8HDAC6MEN1NR1I2 | |
| SCHEMBL6564087 | 0.80 | PLA2G2D (0.49) | HDAC8MEN1KMT2APTPN11 | |
| SCHEMBL8751228 | 0.78 | ALDH1A1 (0.41) | MRGPRX4HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL6564103 | 0.78 | MAOB (0.48) | MRGPRX4HDAC8MEN1MAPTKMT2A | |
| SCHEMBL6565264 | 0.77 | MCHR1 (0.51) | MCHR1TLR8MEN1KMT2ACNR1 | |
| SCHEMBL8629057 | 0.76 | MEN1 (0.52) | PPARGPPARAHDAC8MEN1KMT2A | |
| SCHEMBL8751130 | 0.75 | KDM4E (0.37) | MRGPRX4HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL6565684 | 0.75 | SMN1; SMN2 (0.63) | MRGPRX4MEN1LMNAMAPTKMT2A | |
| SCHEMBL6567160 | 0.75 | MAOB (0.47) | PPARGPPARAMRGPRX4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |