Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564103 | 0.86 | MAOB (0.48) | MAOBMRGPRX4MAPTHTTKDM4E | |
| SCHEMBL6567153 | 0.85 | MAOB (0.48) | MAOBMRGPRX4PPIAMAPTHTT | |
| SCHEMBL6566232 | 0.81 | MAPT (0.48) | MAOBMAPTHTTL3MBTL1KDM4E | |
| SCHEMBL6567309 | 0.80 | MRGPRX4 (0.50) | MAOBMRGPRX4MAPTHTTKDM4E | |
| SCHEMBL8751228 | 0.78 | ALDH1A1 (0.41) | MAOBMRGPRX4MAPTHTTKDM4E | |
| SCHEMBL8628913 | 0.77 | MRGPRX4 (0.50) | MAOBMRGPRX4PPIAMAPTNR4A2 | |
| SCHEMBL8751130 | 0.76 | KDM4E (0.37) | MAOBMRGPRX4MAPTHTTKDM4E | |
| SCHEMBL6564091 | 0.75 | MCHR1 (0.47) | MRGPRX4MAPTPPARGPPARAKDM4E | |
| SCHEMBL8632069 | 0.74 | MAOB (0.48) | MAOBMRGPRX4MAPTHTTL3MBTL1 | |
| SCHEMBL8508415 | 0.73 | MAPT (0.52) | MAOBMRGPRX4MAPTL3MBTL1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |