Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564103 | 0.88 | MAOB (0.48) | MRGPRX4HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6564091 | 0.84 | MCHR1 (0.47) | MRGPRX4MEN1KMT2AKDM4EMAPT | |
| SCHEMBL8751228 | 0.82 | ALDH1A1 (0.41) | MRGPRX4HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6565684 | 0.81 | SMN1; SMN2 (0.63) | MRGPRX4SRD5A1SRD5A2SMN1; SMN2MEN1 | |
| SCHEMBL6567160 | 0.80 | MAOB (0.47) | MRGPRX4HTTKDM4EALDH1A1MAPT | |
| SCHEMBL8751130 | 0.79 | KDM4E (0.37) | MRGPRX4HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6567304 | 0.77 | HDAC8 (0.56) | HPGDSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL6567173 | 0.76 | LMNA (0.49) | HPGDMEN1KMT2AHTTKDM4E | |
| SCHEMBL20067905 | 0.76 | SMN1; SMN2 (0.49) | MRGPRX4SMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL20616566 | 0.76 | SMN1; SMN2 (0.49) | MRGPRX4SRD5A1SRD5A2RXRAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |