Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 5/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6567192 | 0.95 | MCHR1 (0.53) | MCHR1MEN1KMT2APTPN1CNR2 | |
| SCHEMBL6567173 | 0.81 | LMNA (0.49) | MCHR1MEN1KMT2ATP53 | |
| SCHEMBL6565243 | 0.77 | MCHR1 (0.48) | MCHR1MEN1KMT2ATLR8 | |
| SCHEMBL6564091 | 0.77 | MCHR1 (0.47) | MCHR1MEN1KMT2ACNR2CNR1 | |
| SCHEMBL6565257 | 0.76 | TTR (0.41) | MEN1KMT2A | |
| SCHEMBL8751176 | 0.74 | CYP1A2 (0.39) | MCHR1MEN1KMT2ATSHR | |
| SCHEMBL6565261 | 0.74 | PDE3B (0.47) | — | |
| SCHEMBL6564114 | 0.73 | POLB (0.45) | MCHR1MEN1KMT2ATP53TSHR | |
| SCHEMBL6565245 | 0.72 | DAO (0.41) | MEN1KMT2ATSHR | |
| SCHEMBL16160517 | 0.72 | PTPN1 (0.60) | MEN1KMT2APTPN1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |