SCHEMBL6564557

SCHEMBL6564557

Cc1cc(C(O)C(C)(C)C)ccc1-c1cccc(OCc2ccc(C(C)(C)O[SiH2]C(C)(C)C)c(C(C)(C)O[SiH2]C(C)(C)C)c2)c1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 15/20 0.40
NR1H2 P55055 5/20 0.34
NR1H3 Q13133 5/20 0.34
FFAR4 Q5NUL3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6564911 0.93 FFAR1 (0.40) FFAR1NR1H2NR1H3FFAR4
SCHEMBL6564059 0.84 MAOB (0.40) FFAR1FFAR4
SCHEMBL6564184 0.82 RORC (0.37) FFAR1NR1H2NR1H3FFAR4
SCHEMBL6565086 0.82 FFAR1 (0.41) FFAR1NR1H2NR1H3FFAR4
SCHEMBL6565081 0.79 VDR (0.43) FFAR1FFAR4
SCHEMBL6564547 0.75 FFAR1 (0.36) FFAR1NR1H2NR1H3FFAR4
SCHEMBL6882532 0.75 FFAR1 (0.36) FFAR1FFAR4
SCHEMBL6566237 0.71 FFAR1 (0.42) FFAR1FFAR4
SCHEMBL6566235 0.69 VDR (0.43) FFAR1FFAR4
SCHEMBL6158473 0.69 CYP4F2 (0.38) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1235777-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2004-06-16 EP disclosed
EP-1235777-A2 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2002-09-04 EP disclosed
WO-2001038303-A2 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2001-05-31 WO disclosed