Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 13/20 | 0.64 |
| ▸ | METAP1 | P53582 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562801 | 0.89 | METAP2 (0.52) | METAP2METAP1NPC1RAB9ASLC6A9 | |
| SCHEMBL7319788 | 0.83 | METAP2 (0.62) | METAP2METAP1NPC1RAB9ASLC6A9 | |
| SCHEMBL6561605 | 0.83 | METAP2 (0.64) | METAP2METAP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6938795 | 0.83 | METAP2 (0.64) | METAP2METAP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6564663 | 0.80 | METAP2 (0.50) | METAP2METAP1NPC1RAB9ASLC6A9 | |
| SCHEMBL6935836 | 0.80 | METAP2 (0.46) | METAP2METAP1NPC1RAB9A | |
| SCHEMBL6488563 | 0.78 | METAP2 (1.00) | METAP2METAP1NPC1RAB9AL3MBTL1 | |
| SCHEMBL6939040 | 0.77 | METAP2 (0.46) | METAP2METAP1RAB9A | |
| SCHEMBL6938170 | 0.76 | METAP2 (0.49) | METAP2METAP1 | |
| SCHEMBL6564589 | 0.76 | METAP2 (0.49) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | disclosed |