Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 14/20 | 0.64 |
| ▸ | METAP1 | P53582 | 8/20 | 0.53 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564663 | 0.87 | METAP2 (0.50) | METAP2METAP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6564599 | 0.83 | METAP2 (0.64) | METAP2METAP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6938260 | 0.79 | PDK1 (0.45) | METAP2METAP1ALDH1A1 | |
| SCHEMBL6477882 | 0.78 | METAP2 (1.00) | METAP2METAP1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6938170 | 0.78 | METAP2 (0.49) | METAP2METAP1 | |
| SCHEMBL6564589 | 0.78 | METAP2 (0.49) | METAP2METAP1 | |
| SCHEMBL6935836 | 0.75 | METAP2 (0.46) | METAP2METAP1DPEP1 | |
| SCHEMBL6938795 | 0.74 | METAP2 (0.64) | METAP2METAP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7360094 | 0.74 | METAP2 (0.60) | METAP2METAP1PYGLSLC6A2SLC6A4 | |
| SCHEMBL6939040 | 0.72 | METAP2 (0.46) | METAP2METAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | disclosed |