Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 13/20 | 0.46 |
| ▸ | METAP1 | P53582 | 8/20 | 0.46 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6939040 | 0.85 | METAP2 (0.46) | METAP2METAP1HDAC3RAB9A | |
| SCHEMBL6563124 | 0.83 | METAP2 (0.50) | METAP2METAP1DPEP1HDAC3HDAC1 | |
| SCHEMBL6938795 | 0.82 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL6938170 | 0.81 | METAP2 (0.49) | METAP2METAP1KMT2A | |
| SCHEMBL6564599 | 0.80 | METAP2 (0.64) | METAP2METAP1RAB9ANPC1 | |
| SCHEMBL6564589 | 0.77 | METAP2 (0.49) | METAP2METAP1HDAC1KMT2AATM | |
| SCHEMBL6564663 | 0.77 | METAP2 (0.50) | METAP2METAP1RAB9ANPC1 | |
| SCHEMBL6937320 | 0.77 | METAP2 (0.52) | METAP2METAP1KMT2A | |
| SCHEMBL6484295 | 0.76 | METAP2 (0.69) | METAP2METAP1DPEP1HDAC3HDAC1 | |
| SCHEMBL6938260 | 0.76 | PDK1 (0.45) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2003-01-08 | — | — | EP | claimed |
| WO-2001079157-A1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-10-25 | — | — | WO | claimed |