Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 14/20 | 0.49 |
| ▸ | METAP1 | P53582 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938170 | 0.86 | METAP2 (0.49) | METAP2METAP1KMT2A | |
| SCHEMBL6564663 | 0.86 | METAP2 (0.50) | METAP2METAP1 | |
| SCHEMBL6938260 | 0.79 | PDK1 (0.45) | METAP2METAP1 | |
| SCHEMBL6938795 | 0.78 | METAP2 (0.64) | METAP2METAP1EPHX1 | |
| SCHEMBL6561605 | 0.78 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL6483172 | 0.77 | METAP2 (0.64) | METAP2METAP1USP30 | |
| SCHEMBL6935836 | 0.77 | METAP2 (0.46) | METAP2METAP1KMT2AATMHDAC1 | |
| SCHEMBL6564599 | 0.76 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL6939040 | 0.74 | METAP2 (0.46) | METAP2METAP1HDAC6 | |
| SCHEMBL6940184 | 0.73 | METAP2 (0.49) | METAP2METAP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272456-B1 | HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2004-10-27 | — | — | EP | disclosed |