Sugi Predict

Sugi Predict / Compounds / SCHEMBL6565362

SCHEMBL6565362

SCHEMBL6565362

COC(=O)c1c(C(C)C)nc(C(C)C)c(C(=O)OC)c1-c1ccc(F)cc1

nearest known ligand 0.79

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ GCGR P47871 16/20 0.79
▸ LMNA P02545 1/20 0.47
▸ NPC1 O15118 1/20 0.46
▸ CASP3 P42574 1/20 0.46
▸ RAB9A P51151 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ SENP8 Q96LD8 1/20 0.46
▸ SENP7 Q9BQF6 1/20 0.46
▸ SENP6 Q9GZR1 1/20 0.46
▸ DHODH Q02127 1/20 0.43
▸ SLC6A4 P31645 1/20 0.43
▸ SLC6A3 Q01959 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9870958 0.95 GCGR (0.72) GCGRLMNANPC1CASP3RAB9A
SCHEMBL5102048 0.93 GCGR (0.70) GCGRLMNANPC1CASP3RAB9A
SCHEMBL2647513 0.88 GCGR (1.00) GCGR
SCHEMBL14189851 0.88 GCGR (0.67) GCGRLMNANPC1CASP3RAB9A
SCHEMBL2647230 0.87 GCGR (0.80) GCGR
SCHEMBL27525551 0.86 GCGR (0.79) GCGR
SCHEMBL14189850 0.86 GCGR (0.64) GCGRLMNANPC1CASP3RAB9A
SCHEMBL8949663 0.86 GCGR (0.61) GCGRLMNANPC1CASP3RAB9A
SCHEMBL9745151 0.85 GCGR (0.60) GCGRLMNANPC1CASP3RAB9A
SCHEMBL9737768 0.85 GCGR (0.64) GCGRLMNANPC1CASP3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1162197-B1 Process for the preparation of pyridines by oxidation of dihydropyridines using methyl nitrite BAYER CHEMICALS AG (DE) 2004-05-26 — — EP claimed
US-6392050-B2 REACTING 1,4-DIHYDROPYRIDINE WITH METHYL NITRITE IN PRESENCE OF ACID CATALYST BAYER AKTIENGESELLSCHAFT (DE) 2002-05-21 — — US claimed
US-20020002285-A1 Process for preparing substituted pyridines BAYER AKTIENGESELLSCHAFT (DE) 2002-01-03 — — US claimed
US-6392050-B2 REACTING 1,4-DIHYDROPYRIDINE WITH METHYL NITRITE IN PRESENCE OF ACID CATALYST BAYER AKTIENGESELLSCHAFT (DE) 2002-05-21 — — US disclosed
US-20020002285-A1 Process for preparing substituted pyridines BAYER AKTIENGESELLSCHAFT (DE) 2002-01-03 — — US disclosed
US-4997837-A Enzyme inhibitors WARNER-LAMBERT COMPANY (US) 1991-03-05 — — US disclosed
US-4950675-A ANTICHOLESTEROL AGENTS WARNER-LAMBERT COMPANY (US) 1990-08-21 — — US disclosed
US-4906624-A 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis WARNER-LAMBERT COMPANY (US) 1990-03-06 — — US disclosed
EP-0306929-A2 6-[[(Substituted)pyridin-3-YL]alkyl]-and alkenyl]-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis WARNER-LAMBERT COMPANY (US) 1989-03-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020002285-A1 Process for preparing substituted pyridines QDPR, NOX4, NOX5 GCGR 3743/4885LMNA 2882/4885NPC1 4709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.