Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | ACACB | O00763 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6563743 | 0.87 | PRSS1 (0.43) | ACACBF2 | |
| SCHEMBL6563594 | 0.86 | KMT2A (0.51) | ACACBHTTSIRT2KMT2ANPC1 | |
| SCHEMBL6563625 | 0.84 | PRSS1 (0.43) | PKMRAB9AF2ALDH1A1MRGPRX1 | |
| SCHEMBL6565690 | 0.84 | PLAU (0.54) | PLAUHTTSIRT2KMT2ANPC1 | |
| SCHEMBL6563250 | 0.84 | PLAU (0.54) | PLAUACACBHTTSIRT2KMT2A | |
| SCHEMBL6563677 | 0.83 | MRGPRX1 (0.43) | ACACBF2MRGPRX1 | |
| SCHEMBL6565956 | 0.82 | PLAU (0.49) | PLAUACACBHTTSIRT2KMT2A | |
| SCHEMBL6563734 | 0.82 | LTB4R2 (0.45) | ACACBKMT2ANPC1F2ALDH1A1 | |
| SCHEMBL6563749 | 0.82 | ITGB3 (0.41) | ACACBF2ITGB3ITGA2B | |
| SCHEMBL6561827 | 0.80 | MRGPRX1 (0.51) | F2MRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |