Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADH1B | P00325 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH7 | P40394 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28722158 | 0.92 | GNAI3 (0.42) | FAAHMGLLADH1BADH1CADH1A | |
| SCHEMBL17202712 | 0.92 | GNAI3 (0.42) | FAAHMGLLADH1BADH1CADH1A | |
| SCHEMBL29259390 | 0.87 | POLB (0.34) | POLBFAAHMGLLHTTSMN1; SMN2 | |
| SCHEMBL28201323 | 0.86 | GAA (0.36) | POLBFAAHMGLLKMT2AGAA | |
| SCHEMBL22574843 | 0.77 | KDM4E (0.34) | — | |
| SCHEMBL3626761 | 0.75 | PAOX (0.35) | SMN1; SMN2CYP1A2CA12CA1CA2 | |
| SCHEMBL8521645 | 0.71 | CA12 (0.44) | CYP1A2CA12CA1CA2CA7 | |
| SCHEMBL7098874 | 0.70 | ALDH1A1 (0.34) | POLBCYP1A2ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8915607 | 0.69 | GNAI3 (0.41) | POLBFAAHMGLLADH1BADH1C | |
| SCHEMBL16897749 | 0.68 | CHRM2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373494-A2 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | Topo Target A/S (DK) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002078679-A2 | SUCCINIMIDE AND MALEIMIDE DERIVATIVES AND THEIR USE AS TOPOISOMERASE II CATALYTIC INHIBITORS | TOPO TARGET APS (DK) | 2002-10-10 | — | — | WO | disclosed |